Senescence: Anti-aging drug trials “might transform medicine as we know it”

Sept 9, 2017 (Windy Hill Beach, South Carolina) — Is aging a disease that can be treated? A paper published this week in the Journal of the American Geriatrics Society describes why and how senescence researchers are planning preclinical human trials of senolytic drugs. Their abstract states that “In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age-related phenotypes, chronic diseases, geriatric syndromes, and loss of physiological resilience. Among the chronic conditions successfully treated by depleting senescent cells in preclinical studies are frailty, cardiac dysfunction, vascular hyporeactivity and calcification, diabetes mellitus, liver steatosis, osteoporosis, vertebral disk degeneration, pulmonary fibrosis, and radiation-induced damage.” The research, they write, “could transform geriatric medicine by enabling prevention or treatment of multiple diseases and functional deficits”. The following story about the research published in today’s Boston Herald prompted me to look for the journal article. Some of the highlights from the Herald story:

* The therapy aims to correct a phenomenon known as senescence, which is when human cells become zombie-like — they are not active, but they fail to undergo the programmed death that normally occurs at the end of a cell’s lifespan. Although their activity ceases, they give off inflammatory proteins that can cause a variety of diseases, including cancer.

* “I see a future where people will go in and have a dose of this, and reset their clock,” said Harvard University geneticist David Sinclair. “This is one of the biggest developments in the last decade in aging research and in medicine. If it works, it will be transformational for human health.”


FOUNTAIN OF YOUTH?
— lindsay.kalter@bostonherald.com
Boston Herald
Sep 9 2017

A new class of anti-aging therapy is poised for human trials, opening the door to an era of “eternal youth” medicine straight from the pages of a science-fiction novel, say local researchers. “I see a future where people will go in and have a dose of...read more...

The journal article that this story refers to is

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. and Robbins, P. D. (2017), The Clinical Potential of Senolytic Drugs. Journal of the American Geriatrics Society. doi: 10.1111/jgs.14969

The abstract is freely available online at http://onlinelibrary.wiley.com/wol1/doi/10.1111/jgs.14969/abstract where you can access the full article for $6.

2 thoughts on “Senescence: Anti-aging drug trials “might transform medicine as we know it”

  1. Hi Steve.Great article.The benefits of medicines are the helpful effects you get when you use them but risk of it is when you abuse this substance. I’ve read an article somewhere about Xanax and Lorazepam. Taking them together may result in severe depression, seizures, suicidal thoughts, respiratory depression and more.
    Do you agree?

    1. Thanks, Donna. Glad you liked the post. I’m not so well-versed on drug interactions, so I’ll not comment on the drugs you mentioned. Early in my career as a radiation protection technician at commercial nuclear plants, I lived pretty near the National Library of Medicine and spent a lot of time there reading stuff related to my interest in better understanding the biological effects of exposure to ionizing radiation. That led to continued interest over the years in paying attention to stuff like antioxidants, anti-aging, and life extension. I very much appreciate you taking the time to comment here. Know that you’re welcome, wanted and encouraged to come back often. Best wishes, Steve Schulin

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